Following Donna Haraway’s suggestion that "it matters what matters we use to think other matters with; […] what descriptions describe descriptions. […] It matters what stories make worlds, what worlds make stories" (Haraway, 2016), this work examines the human quest for extraterrestrial life and how our search is constrained by an Earth-centric definition of life. An example of this is NASA's definition of life as "a self-sustaining chemical system capable of Darwinian evolution." Currently, there exist over 100 definitions of life, yet we continue to encounter organisms on Earth that challenge our understanding of what constitutes a life form. Extremophiles, viruses, and chemical systems displaying life-like behaviors are expanding our conception of life and suggesting that we may not possess a comprehensive understanding to effectively seek life on other planets. This work speculates about forms of life that elude our imagination and considers the possibility of life evolving on Mars, potentially influenced by our own contamination resulting from our prolonged presence and the deployment of our machines.